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version: "1.0.1" name: snp_functional_analysis description: "SNP Functional Impact Analysis - Analyze SNP function: VEP prediction, variation details, phenotype association, and literature evidence. Use this skill for functional genomics tasks involving get vep id get variation get phenotype accession pubmed search. Combines 4 tools from 2 SCP server(s)."
SNP Functional Impact Analysis
Discipline: Functional Genomics | Tools Used: 4 | Servers: 2
Description
Analyze SNP function: VEP prediction, variation details, phenotype association, and literature evidence.
Tools Used
- `get_vep_id` from
ensembl-server(streamable-http) -https://scp.intern-ai.org.cn/api/v1/mcp/12/Origene-Ensembl - `get_variation` from
ensembl-server(streamable-http) -https://scp.intern-ai.org.cn/api/v1/mcp/12/Origene-Ensembl - `get_phenotype_accession` from
ensembl-server(streamable-http) -https://scp.intern-ai.org.cn/api/v1/mcp/12/Origene-Ensembl - `pubmed_search` from
search-server(streamable-http) -https://scp.intern-ai.org.cn/api/v1/mcp/7/Origene-Search
Workflow
- Predict functional effects with VEP
- Get variant details
- Get phenotype associations
- Search PubMed for evidence
Test Case
Input
json
{"variant_id": "rs1800497","species": "homo_sapiens"}
Expected Steps
- Predict functional effects with VEP
- Get variant details
- Get phenotype associations
- Search PubMed for evidence
Usage Example
Note: Replace<YOUR_SCP_HUB_API_KEY>with your own SCP Hub API Key. You can obtain one from the SCP Platform.
python
import asyncioimport jsonfrom mcp import ClientSessionfrom mcp.client.streamable_http import streamablehttp_clientfrom mcp.client.sse import sse_clientSERVERS = {"ensembl-server": "https://scp.intern-ai.org.cn/api/v1/mcp/12/Origene-Ensembl","search-server": "https://scp.intern-ai.org.cn/api/v1/mcp/7/Origene-Search"}async def connect(url, transport_type):transport = streamablehttp_client(url=url, headers={"SCP-HUB-API-KEY": "<YOUR_SCP_HUB_API_KEY>"})read, write, _ = await transport.__aenter__()ctx = ClientSession(read, write)session = await ctx.__aenter__()await session.initialize()return session, ctx, transportdef parse(result):try:if hasattr(result, 'content') and result.content:c = result.content[0]if hasattr(c, 'text'):try: return json.loads(c.text)except: return c.textreturn str(result)except: return str(result)async def main():# Connect to required serverssessions = {}sessions["ensembl-server"], _, _ = await connect("https://scp.intern-ai.org.cn/api/v1/mcp/12/Origene-Ensembl", "streamable-http")sessions["search-server"], _, _ = await connect("https://scp.intern-ai.org.cn/api/v1/mcp/7/Origene-Search", "streamable-http")# Execute workflow steps# Step 1: Predict functional effects with VEPresult_1 = await sessions["ensembl-server"].call_tool("get_vep_id", arguments={})data_1 = parse(result_1)print(f"Step 1 result: {json.dumps(data_1, indent=2, ensure_ascii=False)[:500]}")# Step 2: Get variant detailsresult_2 = await sessions["ensembl-server"].call_tool("get_variation", arguments={})data_2 = parse(result_2)print(f"Step 2 result: {json.dumps(data_2, indent=2, ensure_ascii=False)[:500]}")# Step 3: Get phenotype associationsresult_3 = await sessions["ensembl-server"].call_tool("get_phenotype_accession", arguments={})data_3 = parse(result_3)print(f"Step 3 result: {json.dumps(data_3, indent=2, ensure_ascii=False)[:500]}")# Step 4: Search PubMed for evidenceresult_4 = await sessions["search-server"].call_tool("pubmed_search", arguments={})data_4 = parse(result_4)print(f"Step 4 result: {json.dumps(data_4, indent=2, ensure_ascii=False)[:500]}")# Cleanupprint("Workflow complete!")if __name__ == "__main__":asyncio.run(main())